In addition, sequencing of DNA from sIBM patients has interestingly identified rare missense variants in proteins regulating protein processing, such as sequestosome 1 (SQSTM1/p62) and valosin containing protein (VCP/p97) (34), the latter a previously reported autoantibody target in primary biliary cholangitis (35). This evidence concerns the gene VCP and primary biliary cholangitis.