Several studies have described the phenomenon of reduced Tresp cell sensitivity to the suppressive function of Treg cells in various autoimmune diseases, including T1D (38), systemic lupus erythematosus (39), rheumatoid arthritis (40), and juvenile idiopathic arthritis (41), which also have been shown to be associated with lymphopenia and elevated IL-7 levels (42). This evidence concerns the gene IL7 and rheumatoid arthritis.