The F1F3 chimera increased the NH36 specific IgA (Figure 1) and IgG2a (Figure 2) antibody responses, and was stronger than the other formulations, both before and after infection, while it enhanced the IgM and titers before infection, and the IgG (Figure 1) and IgG3 levels after challenge (Figure 2). The gene discussed is IGHG3; the disease is infection.