NKp44 engagement by PCNA results in the inhibition of NK-mediated cytotoxicity and IFN-γ secretion by NK cells; this inhibitory effect is mediated by the ITIM in NKp44 cytoplasmic tail and is observed only following an interaction with the ITIM-containing isoform NKp44-1, whose expression has been associated with poor survival in AML patients (36). Here, NCR2 is linked to acute myeloid leukemia.