Typically, NKp44 is implicated in the killing of virus-infected or tumor cells; however, the increasing panel of NKp44+ cells and the identification of new NKp44-ligands (NKp44L), possibly expressed in different tissues or released in the circulation, supports an important role for this receptor in tissue homeostasis and immune regulation (25–29). This evidence concerns the gene KMT2E and neoplasm.