In contrast to the frequency of CD45RA+ Tregs, the frequency of intermediate monocytes was positively correlated with the frequency of Foxp3+CD25+CD45RO+ Tregs and Foxp3+Helios+CD45RO+ Tregs in the CHI group (Figure 3A) and the CHI&RPR+ group (Figure 3B). The gene discussed is FOXP3; the disease is congenital isolated hyperinsulinism.