NT5E and neoplasm of thorax: On the other hand, the pathologic role of the radiation-induced increase in CD73/adenosine signaling in promoting chronic inflammation and fibrosis in the normal lung tissue strongly suggest that pharmacologic inhibition of CD73/adenosine offers the opportunity for widening the therapeutic window by reducing radiation-induced lung toxicity, particularly in CD73-rich thoracic tumors with a high risk for CD73-dependent normal tissue toxicity.