By releasing several cytokines, chemokines, or growth factors as well as up-regulating specific surface receptors e.g., immunosuppressive PD-L1, cytotoxic T-lymphocyte-associated Protein 4 (CTLA-4), carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1), and others, tumor cells become proficient in dampening immune responses and to escape the immune system (91–96). The gene discussed is CTLA4; the disease is neoplasm.