CD4 binding site bnAbs b12 IgG1 and CH31 IgG1 and IgA2 isoforms potently blocked HIV-1JR-CSF and HIV-1Bal26 infection. However, IgG1 and IgA nnAbs, either alone, or together, did not inhibit infection despite the presence of FcR-expressing effector cells in the tissue. This evidence concerns the gene CD79A and infection.