MiR-155HG is processed to give miR-155, and inhibitors of miR-155 have been reported to decrease IL-13 and IL-5 expression by Th2 cells, and miR-155-deficient mice exhibited reduced airway inflammation and eosinophilia in response to house dust mite challenge or a model of ovalbumin-induced allergic airway inflammation (55, 56). This evidence concerns the gene IL5 and inflammatory response.