KLRK1 and neoplasm: In order to find the activating receptors responsible for lysing PDAC cells, blocking mAbs against ICAM-1, DNAM-1, NKG2D, and/or NCR (NKp46, NKp44, NKp30) were added to in vitro51Cr-release assays using MIA PaCa-2 or autologous tumor cells as targets (Figures 5B,C).