Bifidobacterium breve (Ranking ninth in the prediction list) can serve as an anti-inflammatory agent to inhibit the expression and release of inflammatory mediators in COPD by inhibiting the activity of NF-kB induced by cigarette smoke which is the main cause of COPD (Mortaz et al., 2015). The gene discussed is NFKB1; the disease is chronic obstructive pulmonary disease.