HUCBC and BMSC treatment of type 2 diabetic stroke rats also had an effect on macrophage polarization, promoting decreases inflammation (42, 46), decreased the expression of the proinflammatory protein toll-like receptor 4 (TLR4) (42), increasing brain platelet-derived growth factor (PDGF) expression in the ischemic brain, contributing to restoration (46) and promoting functional improvement after stroke (42). Here, TLR4 is linked to Stroke.