Single-locus analysis suggested that the rs619586 G variant in lncRNA MALAT1 was associated with decreased recurrent miscarriage susceptibility (AG vs. AA: adjusted OR = 0.670, 95% CI = 0.457–0.982, p = 0.040; GG vs. AA: adjusted OR = 0.278, 95% CI = 0.079–0.975, p = 0.046; GG/AG vs. AA adjusted OR = 0.621, 95% CI = 0.429–0.900, p = 0.012). The gene discussed is MALAT1; the disease is spontaneous abortion.