Research has confirmed that the rs619586 G allele of the MALAT1 gene is associated with a decreased risk of coronary atherosclerotic heart disease (Wang G. et al., 2018), and genetic variations in MALAT1 (rs591291) showed a significantly better hepatocellular cancer prognoses in female patients (Wang B.G. et al., 2018). Here, MALAT1 is linked to hepatocellular carcinoma.