PRKN and hydrops fetalis: However, cell treated with 1 μM TAT-MP2Gly, which suppressed fusion-mediated content exchange by MFN2 (Franco et al., 2016), led to a decrease in of Parkin puncta and LC3-mediated autophagosome formation in aged control myocytes but did not affect these parameters significantly in HF myocytes, suggesting that mitochondrial content exchange and trafficking was already suppressed in HF.