HTR2A and migraine disorder: However, all the classic oral preventative treatments including tricyclic antidepressants, beta blockers, 5-HT2 antagonists ergots and anti-epileptic drugs were not developed for migraine and provide 50% reduction in the number of monthly days of migraine pain only up to the 45% of migraineurs (D’Amico and Tepper, 2008), also because of low adherence due to scarce tolerability.