Intriguingly, the supplement of exogenous Klotho could alleviate renal fibrosis by inhibiting endoplasmic reticulum stress and EMT (Liu et al., 2015, 2017), targeting canonical TGF-β1 (Doi et al., 2011) or Wnt/β-catenin signaling (Satoh et al., 2012), or the renin-angiotensin system (Zhou et al., 2015). Here, TGFB1 is linked to renal fibrosis.