NUDT15 and Decreased total leukocyte count: Another study involving 253 Chinese IBD patients found that the NUDT15 variant was correlated with the early, middle (8–24 weeks) and late (>24 weeks) phases of leukopenia (OR = 15.67, 12.06, and 3.91, respectively; P = 2.13 × 10−19, 4.51 × 10−9 and 0.022, respectively) (Zhu et al., 2016).