It has been reported that the vascular endothelial growth factor (VEGF)-induced cancer cell angiogenesis can be down-regulated by the activation of CBRs in skin carcinomas (Casanova et al., 2003), gliomas (Blázquez et al., 2003, 2004) and thyroid carcinomas (Portella et al., 2003). This evidence concerns the gene VEGFA and central nervous system cancer.