MGLL and neoplasm: This opinion is reinforced by in vivo reports that the deletion of CB1R accelerates tumor growth (Wang et al., 2008), that the presence of higher endocannabinoid levels lead to a reduction of precancerous lesions (Izzo et al., 2008), and that lower expression of MAGL decreases tumor growth (Nomura et al., 2010; Velasco et al., 2015).