VEGFA and skin carcinoma: It has been reported that the vascular endothelial growth factor (VEGF)-induced cancer cell angiogenesis can be down-regulated by the activation of CBRs in skin carcinomas (Casanova et al., 2003), gliomas (Blázquez et al., 2003, 2004) and thyroid carcinomas (Portella et al., 2003).