In glioma cells, the same level of inhibition of cannabinoid-induced cell death is achieved by antagonizing CB1R or CB2R, but in pancreatic, breast of hepatic cells only CB2R antagonists are effective (Galve-Roperh et al., 2000; Carracedo et al., 2006a; Caffarel et al., 2006; Lorente et al., 2011; Vara et al., 2011). This evidence concerns the gene CNR1 and central nervous system cancer.