ERBB2 and breast cancer: In breast cancer, the overexpression of the tyrosine kinase receptor (TKR) human V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog 2 (HER2) is a particular hallmark of one type of this disease (Perou et al., 2000; Sorlie et al., 2001; Sotiriou et al., 2003; Curtis et al., 2012).