Additionally, CB1R and/or CB2R agonists lead to an inhibition of adhesion and local and distant invasion in induced and spontaneous metastatic in vitro and in vivo models of glioma, breast, lung, and cervical cancer (Grimaldi et al., 2006; Blázquez et al., 2008; Preet et al., 2008; Ramer and Hinz, 2008; Qamri et al., 2009). Here, CNR1 is linked to central nervous system cancer.