Beside CB1R and CB2R, other receptors have been found to be the targets of endocannabinoids and exocannabinoids in the CNS and in tumor tissues, including the transient receptor potential channels, ligand and voltage-gated ion channels and other orphan G protein-coupled receptors as GPR55, GPR18 and GPR119 (Soderstrom et al., 2017). Here, CNR1 is linked to neoplasm.