Moreover, one of the most important downstream targets of both Raf and AKT is NF-κB (Yajima et al., 2012), which is considered a potential key player in the treatment of melanoma (Madonna et al., 2012) and a major orchestrator in the initiation and propagation of colorectal cancer (Vaiopoulos et al., 2013). Here, NFKB1 is linked to melanoma.