IGHE and asthma: Various in vitro studies have demonstrated the role of ERK MAPK in important aspects of asthma pathogenesis, including goblet cell hyperplasia (Atherton et al., 2003), eosinophil migration (Boehme et al., 1999), extracellular matrix protein secretion (Kazi et al., 2004), Th2 cytokine production (Puig-Kroger et al., 2001), and IgE production (Basaki et al., 2002).