IGHE and asthma: p38 MAPK is the most extensively studied MAPK in asthma, and activation of p38 MAPK has been shown to cause eosinophil differentiation and activation (Adachi et al., 2000), mast cell migration (Ishizuka et al., 2001), IgE synthesis (Marshall et al., 1998), Th2 reaction aggravation (Huang L. et al., 2018), and airway remolding (Zhai et al., 2004).