ITGAM and Alzheimer disease: The TC group exhibited a significantly and strongly reduced ratio of M2 (CD11b+CD206+cells) and M1 (CD11b+CD86+cells) microglia (1.09 ± 0.17) compared to the WC group (4.01 ± 0.11; p < 0.01, Figure 6), suggesting that the activated microglia were polarized predominantly to an M1 phenotype in AD.