ABCA7 and Alzheimer disease: In particular, the ABCA7 single nucleotide polymorphism (SNP) rs3764650 has been implicated in influencing ABCA7 expression levels in the brain (Vasquez et al., 2013), and corresponds to ~10%–20% increased risk of AD in Caucasians (Hollingworth et al., 2011; Naj et al., 2011).