Furthermore, in a previous study we investigated the effect of ABCA7 rs115550680, a variant with a significantly increased risk for AD exclusively in African-Americans (Reitz et al., 2013), on the same behavioral paradigm; we found that non-demented African American elderly with the ABCA7 rs115550680 risk genotype had impairments in generalization, mediated by cortico-hippocampal network dysfunction (Sinha et al., 2018). The gene discussed is ABCA7; the disease is Alzheimer disease.