BDNF and early-onset autosomal dominant Alzheimer disease: Further research has extended this concept and showed that adult hippocampal neurogenesis combined with increased BDNF levels mimic the beneficial cognitive effects promoted by exercise in a mouse model of Alzheimer’s disease and suggest that enhancing neurogenesis and BDNF levels at early stages of the disease may protect against subsequent neuronal cell death (Choi et al., 2018).