TH and hypothyroidism: Given that hypothyroidism has been associated with functional and structural alterations within the cerebellum (Koibuchi, 2008), hippocampus (Gould et al., 1990a; Gilbert et al., 2007), cortex (Royland et al., 2008) and subcortical nuclei (Yasuda et al., 2000), TH are expected to have global impacts on brain functions.