A20 has been reported as a rheumatoid arthritis susceptibility gene (Nititham et al., 2015), and reducing A20 expression in macrophages by myeloid-cell-specific deletion of the gene A20 in mice promptly aggravates rheumatoid arthritis by reducing lipopolysaccharide (LPS)-induced NLR family, pyrin domain-containing 3 (NLRP3) expression levels and negatively regulating NLRP3 inflammasome activation (Vande Walle et al., 2014). Here, NLRP3 is linked to rheumatoid arthritis.