MAPT and Alzheimer disease: Alzheimer’s disease (AD), the most common cause of dementia in elderly population, is characterized by complicated and multifactorial pathophysiological alterations, primarily including senile plaque deposits, Tau protein hyperphosphorylation, high oxidative stress, metal ion dyshomeostasis, and neurotransmitter system irregularities (Ballard et al., 2011; Chiang and Koo, 2014).