Furthermore, the ability of LC1405 in reversing the effects of AD and underlying mechanisms were evaluated in APP/PS1 double transgenic mice, and SH-SY5Y cells that express APP with a familial Swedish mutation, both excessively expressing the APP gene and mimicking β-amyloidogenic disturbance (Zhang et al., 2006; Voss et al., 2014). The gene discussed is PSEN1; the disease is Alzheimer disease.