Oxidative stress is implicated in the pathology of AD, and in this study, the APP/PS1 mouse model displayed alterations in markers of oxidative stress in the brain, such as MDA, SOD, and GSH-Px compared to WT control group (Figure 2G–I) (MDA: 59.63 ± 3.32 nmol/mg protein vs. 27.87 ± 2.69 nmol/mg protein; SOD: 76.33 ± 2.25 U/mg protein vs. 126.78 ± 8.72 U/mg protein; GSH-Px: 3.62 ± 0.35 U/mg protein vs. 7.78 ± 0.47 U/mg protein; all p < 0.001). This evidence concerns the gene SOD1 and Alzheimer disease.