NOTCH1 and amyotrophic lateral sclerosis: To our knowledge, this is the first study to analyse the Notch signalling pathway in biological samples taken in tissue samples from the hippocampus from patients with ALS; In a recent paper, Nonneman et al. (2018) found that Notch signalling pathway is activated in the reactive astrocytes in the spinal cord of SOD1hG93A mice, as well as in patients with sporadic ALS and their finding of a upregulation of astrocytic Jagged-1 is in concordance with the our finding of the greater expression of Notch1 in our cases.