NOTCH1 and neurodegenerative disease: Notch1 overexpression has previously been observed in other neurodegenerative diseases (Nagarsheth et al., 2006; Lathia et al., 2008) activation of the Notch signalling pathway has been found to play a role in ageing and memory (Ables et al., 2011; Alberi et al., 2013).