Our results show that expression of markers of proliferation (Ki67), differentiating cells (GFAPδ), and differentiation (PSA-NCAM) is significantly correlated with NICD expression and negatively correlated with Notch1, which suggests that decreased neurogenesis in ALS (Galán et al., 2017) may be associated with Notch signalling pathway inactivation. This evidence concerns the gene NCAM1 and amyotrophic lateral sclerosis.