An assessment of overlapping canonical signaling systems reveals that the top highly up/down-regulated pathways all play important potential or predicted roles in governing melanoma metastasis: PPAR/RXRα, angiopoietin signaling, mTOR, Semaphorin signaling between the Stroke-MET and OGDEC-MET transcriptome, and ephrin receptor signaling in both Stroke-MET and OGDAstro-MET transcriptomes (Figure 9A,B). The gene discussed is RXRA; the disease is melanoma.