GBA1 and Parkinson disease: High-throughput screening identified the compounds NCGC607 and NCGC00188758 and the chaperone ambroxol, which restore glucocerebrosidase activity and rescue PD-related phenotypes in DAn from GBA carriers (Aflaki et al., 2016; Mazzulli et al., 2016; Yang et al., 2017).