In a murine model of diet-induced NASH, α7nAChR KO chimeric mice (produced by transplanting α7nAChR bone marrow cells into γ-irradiated and Kupffer cell-depleted wild-type recipients) develop an accelerated form of disease (Nishio et al., 2017). This evidence concerns the gene CHRNA7 and metabolic dysfunction-associated steatohepatitis.