Lima et al. 13 showed that independent of alterations in the systemic levels of the M1 activated macrophages, the monocytes-derived chemerin receptor (CMKLR1)-expressing M1 ovarian macrophages are predominantly involved in the processes of antral growth arrest and granulosa cell apoptosis reported in the DHT-induced PCOS in rats13. Here, CMKLR1 is linked to polycystic ovary syndrome.