Conversely, in a case control study on the clinical significance of ADAMTS proteinases, IL17, IL23 and IL33 in PCOS, Karakose and coworkers37 reported significantly higher levels of these cytokines in the serum of overweight (BMI ≥ 25) PCOS patients compared to controls and suggested a pathogenic role of these molecules in the etiology of PCOS. This evidence concerns the gene IL17A and polycystic ovary syndrome.