Furthermore, we verified direct impairment of protein biosynthesis, including disruption of ribosome biogenesis due to down-regulation of the genes NOP1, NSR1; although this can be partially composed through up-regulation of the gene RPS15. A review at the CTD48 revealed that RPS15 is a marker of Disease Progression, including memory impairment in transgenic mice modelingAD treated with copper79 as well as RPL14, potentially affected by Mn, is a marker of PD), which have been observed in case of residential exposure to maneb,. This evidence concerns the gene RPL14 and memory impairment.