Moreover, it was found to regulate the transcriptional activity of zinc finger E-box-binding protein 2 (ZEB2) and to bind directly to the promoter region of ZEB2. Further, the PAX6-ZEB2 axis was determined to promote metastasis by mediating E-cadherin downregulation through the PI3K/AKT pathway in NSCLC. The gene discussed is ZEB2; the disease is non-small cell lung carcinoma.