Results of RT-PCR and western blotting showed that GSTP1 was obviously upregulated in CRC and colon of FBX8 KO mice treated with AOM-DSS tissues, while FBX8 was downregulated in CRC tissues compared to adjacent normal tissues (Figs. 6d, f, S4D), and the level of FBX8 was negatively correlated with that of GSTP1 in clinical CRC tissues and cancerous tissues of FBX8-KO/AOM-DSS mice and FBX8(+/+)/AOM-DSS mice (Fig. 6c, R2 = 0.789, P = 0.000; Fig. 6e, r = −0.471, P = 0.0485). Here, GSTP1 is linked to infectious otitis media.