Meanwhile, the level of Caspase 3 was decreased and the level of Ki-67 was increased in FBX8-KO/AOM-DSS mice, compared with FBX8-WT and FBX8-WT/AOM-DSS mice, which were consistent with the supression of FBX8 in cell proliferation of CRC9 (Fig. 1c, e). This evidence concerns the gene CASP3 and infectious otitis media.