RIPK1−/− mice are not viable31 so that RIPK1 was knocked down in BMDMs using siRNA (Fig. 5d) and again, in agreement with a recent paper32, the knockdown of RIPK1 did not impact the inflammasome nor the viral replication following infection (Fig. 5d, S7), while it did prevent MLKL phosphorylation following necroptosis induction (Fig. S9A). The gene discussed is RIPK1; the disease is infection.