After VSV or EMCV infection, despite NLRP3 inflammasome activation, cell death was not affected in NLRP3, ASC, or caspase-1-deficient BMDMs or after treatment with a broad caspase inhibitor like zVAD-fmk, suggesting that pyroptotic or apoptotic cell death was not involved. The gene discussed is CASP1; the disease is infection.