Creb1 dysregulation is likely to be involved in Alzheimer’s disease65, Parkinson’s disease, Huntington’s disease, Rubinstein-Taybi syndrome, ischemia, alcoholism, schizophrenia, addiction, and depression (reviewed in Sakamoto et al.62 and Thakur et al.66). The gene discussed is CREB1; the disease is depressive symptom measurement.