SIRT1 and atherosclerosis: As shown in Fig. 7b, atherosclerotic plaques formed in the aortic sinus of WT mice fed a high-fat diet for 12 weeks, but was significantly attenuated in SIRT1 TG mice, suggesting that SIRT1 represents a potential therapeutic target for vascular inflammation, including atherosclerosis, by reducing monocyte adhesion to the vascular endothelium.