Two mutations of ApoA-I have been reported, namely, ApoA-I Milano (apoA-IM) and ApoA-I Paris, in which ApoA-IM shows distinct effects of very low high-density lipoprotein cholesterol (HDL-C) levels and moderate hypertriglyceridemia but without evidence of premature CAD, preclinical coronary or carotid atherosclerosis [7,8]. The gene discussed is APOA1; the disease is carotid atherosclerosis.