It is argued that the association between 25OHD and CRC risk/survival might reflect the influence of the SIR to CRC or its treatment on 25OHD.9 15 Indeed, CRP, a marker of inflammation, is also correlated with both CRC risk35 and survival.29 36 However, the current study provides evidence against CRP as a confounding variable in observational studies of 25OHD and CRC risk/outcome. The gene discussed is CRP; the disease is colorectal carcinoma.