APOE and Alzheimer disease: In contrast to APOE ε4, while a PGS for AD was associated with a lower NART score, this was not associated with the ACE-III, although scores based on the same IGAP database used as a reference for the PGS in this study are predictive of AD itself.41 The lack of association between a PGS for AD and general cognitive ability is consistent with a recent study using the Lothian birth cohort,42 although these authors found an association for cognitive slope (but not intercept) with a more stringent whole-genome threshold (0.01) than ours (0.05).