However, analysis of another tissue microarray containing 59 melanoma samples with detailed survival information showed that high expression of Ku80 was associated with poor prognosis in melanoma patients (Fig. 11D), and patients with high levels of both Ku80 and PDK1 had worse prognosis than those with low expression of Ku80 and PDK1 (Fig. 11E). The gene discussed is XRCC5; the disease is melanoma.