In contrast, hypermethylation in C3 (IDH-O), and to a less degree in C1 (IDH-wt) and C2 (IDH-A), is observed for targets of the polycomb repressive complex 2 (PRC2) in de-differentiated tumor cells [3], for related compounds such as SUZ12 and EED targets and for bivalently H3K4me3 and H3K27me3 marked genes in poised promoter states that are enriched in tumor suppressors [41]. Here, EED is linked to neoplasm.