The anti-inflammatory role of S100A8 and S100A9 are further indicated by the finding that glucocorticoids directly induce these proteins in human monocytes and dendritic cells, and that S100A8-positive macrophages are increased in synovial fluid after treatment of rheumatoid arthritis patients with high-dose methylprednisolone [34]. The gene discussed is S100A9; the disease is rheumatoid arthritis.