In 2016, mutations of CAPN1 [c.884G > C (p.R295P), c.1579C > T (p.Q527*), c.406delC (p.P136Rfs*40) and c.1605 + 5G > A] were identified in three AR inherited HSP pedigrees for the first time [7]. This evidence concerns the gene CAPN1 and hereditary spastic paraplegia.