In our study, although the TCGA data showed that EHD1 was positively correlated with β2AR mRNA expression in NSCLC, the in vitro experiment results showed that EHD1 did not positively regulate β2AR mRNA expression and that the aberrant β2AR signaling pathway did not regulate EHD1 expression. The gene discussed is ADRB2; the disease is non-small cell lung carcinoma.