According to the data obtained from the TCGA database, EHD1 expression was positively correlated with β2AR expression (Additional file 10: Figure S5a) and the expression of the downstream gene hypoxia-inducible factor (HIF)-1α (Additional file 10: Figure S5b) in lung squamous cell carcinomas and lung adenocarcinoma in the TCGA cohort. Here, ADRB2 is linked to lung adenocarcinoma.