The fact that SOM is released into circulation from the activated TRPV1-expressing nociceptors (LPS also activates the sensory nervous system by sensitizing TRPV1) and the presence of somatostatin receptor type 4 in the DRG and in spinal cord cause the possible occurrence of a novel potential drug on even such excruciating pain as bone cancer pain [84, 85]. Here, GRHL3 is linked to bone cancer.