Increased Nrf2 levels have been shown in many clinical cancer studies including melanoma, lung, ovarian and endometrial carcinomas, pancreatic cancer, renal cancer, breast, colorectal cancer and hepatocellular carcinoma, and etc. Table 1 [59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77,78]. The gene discussed is NFE2L2; the disease is hepatocellular carcinoma.