The aim of this study is to investigate the role of selected SNPs of the NR3C1 (rs6190, rs6189, bcl2, and rs41423247), of the FKBP5 (rs4713916), of the GLCCI1 (rs37972) and of the MDR1 (rs2032582) gene in modulating the effect of CSs on therapeutic endpoints in a group of COPD patients. The gene discussed is FKBP5; the disease is chronic obstructive pulmonary disease.