Importantly, when combining GPVI-deficiency together with rt-PA treatment after tMCAO, an experimental setting that closely resembles the current clinical treatment situation where patients with a severe ischemic stroke (caused by large-vessel-occlusion) are treated by mechanical recanalization with the concomitant pharmacological support of IV administered rt-PA, the lack of GPVI was still safe and effective. The gene discussed is GP6; the disease is ischemic stroke.