LDLR and Hepatic fibrosis: With respect to n3-PUFA intervention, others have reported that DHA consumption resulted in greater suppression of hepatic fibrosis markers at the mRNA level compared to EPA in Ldlr-/- mice fed a Western-type diet [8], whereas Suzuki-Kemuriyama et al [10] found that both DHA and EPA decreased hepatic fibrosis assessed by α-SMA protein levels in mice fed an atherogenic high-fat diet.