Botelho et al [9] found that Echium oil (ALA + stearidonic acid) and fish oil (EPA + DHA) but not algal oil (DHA) reduced hepatic steatosis (assessed histologically) when Ldlr-/- mice fed high fat diets were provided the oils by gavage for four weeks; the attenuation in hepatic steatosis with the Echium oil was attributed to a reduced n6/n3 ratio in liver. The gene discussed is LDLR; the disease is fatty liver disease.