We present herein a novel series of [18F]fluoroethyltriazolyl-containing monocyclam derivatives and highlight in particular [18F]RPS-534 and [18F]RPS-547, which demonstrate improved CXCR4-dependent tumor uptake and tumor-to-background ratios over [18F]RPS-544. The gene discussed is CXCR4; the disease is neoplasm.